Key result
NAFLD with diabetes was associated with significantly lower overall heart rate variability (SDNN, total power) compared to controls, with diabetic status playing a critical role.
Why the study?
Does NAFLD and diabetic status affect heart rate variability?
Cross-Sectional (n=75)
Does NAFLD and diabetic status affect heart rate variability?
Diabetic status and the grade of NAFLD contribute to decreased cardiovascular autonomic function, potentially mediated by adiposity and serum lipids.
May indicate elevated autonomic risk in diabetic NAFLD; hypothesis-generating for prospective validation of HRV modulation.
Aim. The present study was designed to evaluate the heart rate variability (HRV) in nonalcoholic fatty liver disease (NAFLD) and to assess the effect of grade of NAFLD and diabetic status on HRV. Methods. This cross-sectional study included 75 subjects (25 NAFLD without diabetes, 25 NAFLD with diabetes, and 25 controls). Measurements included anthropometry, body composition analysis, estimation of plasma glucose, serum lipids, hsCRP, and serum insulin. HRV analysis was performed in both time and frequency domains. Results. The time and frequency domain indices of overall variability (SDNN, total power) were significantly lower in NAFLD with diabetes as compared to the controls. However, the LF : HF ratio did not differ among the three groups. The variables related to obesity, lipid profile, and glucose metabolism were also higher in NAFLD with diabetes and those with Grade II NAFLD without diabetes, as compared to controls. Multivariate stepwise regression analysis showed a negative correlation between HRV and total cholesterol and fat percentage. Conclusion. The grade of NAFLD as well as diabetic status contributes to the decrease in the cardiovascular autonomic function, with diabetic status rather than grade of NAFLD playing a critical role. Serum lipids and adiposity may also contribute to cardiac autonomic dysfunction.
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Kumar et al. (2016) conducted a cross-sectional in Nonalcoholic fatty liver disease (NAFLD) (n=75). Nonalcoholic fatty liver disease (NAFLD) and diabetes vs. Controls was evaluated on Heart rate variability (HRV) indices (SDNN, total power). NAFLD with diabetes was associated with significantly lower overall heart rate variability (SDNN, total power) compared to controls, with diabetic status playing a critical role.
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