Key result
Obesity in patients with type 2 diabetes did not significantly alter median VEGF mRNA expression compared to non-obese patients, but BMI strongly correlated with VEGF, flt-1, and KDR expression levels (r>0.86, p<0.001).
Why the study?
The study was designed to investigate parameters of the angiogenesis system in patients with diabetes mellitus and determine their relationship with obesity.
Does obesity correlate with altered angiogenesis system parameters (VEGF, flt-1, KDR mRNA expression) in patients with type 2 diabetes mellitus?
Cross-Sectional (n=104)
No
Does obesity correlate with altered angiogenesis system parameters (VEGF, flt-1, KDR mRNA expression) in patients with type 2 diabetes mellitus?
Absolute Event Rate: 0.25% vs 0.28%
p-value: p=0.71
In patients with type 2 diabetes mellitus, body mass index strongly correlates with the mRNA expression of VEGF and its receptors, suggesting a link between obesity and altered angiogenesis.
AIM: To investigate parameters of angiogenesis system in patients with diabetes mellitus and their relationship with obesity. MATERIALS AND METHODS: 104 patients with diabetes mellitus type 2 were included in the study. Patients were divided in 2 groups: Obesity+ (body mass index30 kg/m2;n=63) and Obesity- (body mass index 30 kg/m2;n=41). In all patients was performed clinico-diagnostical examination. mRNA expression levels of vascular endothelial growth factor (VEGF), its receptors flt-1 (fms-like tyrosine kinase 1), KDR (human kinase insert domain receptor) were determined in blood mononuclear cells. RESULTS: There were no statistically significant differences in investigated parameters between study groups. mRNA expression level of VEGF was slightly lower in men compared to women: 0.19 (0.14; 0.32)vs0.28 (0.12; 0.4) respectively,р=0.2236. MRNA expression level of flt-1 was lower in men compared to women: 0.14 (0.04; 0.3)vs0.25 (0.12; 0.38),р=0.0321 (statistically significant). We found statistically significant correlations of mRNA expression level of VEGF with mRNA expression level of flt-1 and KDR. Also we found strong positive correlations of BMI and mRNA expression levels VEGF, flt-1, KDR (r=0.86107,r=0.86125,r=0.86112, respectively,p0.001). CONCLUSION: Results of the study displayed relationship of obesity and angiogenesis system condition in patients with diabetes mellitus type 2. Further investigations are perspective for the future as a way to new therapeutical approach of obesity and its complications treatment.
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Северина et al. (2020) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=104). Obesity (BMI ≥30 kg/m2) vs. Non-obese (BMI <30 kg/m2) was evaluated on VEGF mRNA expression level in blood mononuclear cells (p=0.71). Obesity in patients with type 2 diabetes did not significantly alter median VEGF mRNA expression compared to non-obese patients, but BMI strongly correlated with VEGF, flt-1, and KDR expression levels (r>0.86, p<0.001).
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