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May 15, 2000Blood

The role of platelet α-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells

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Population

Primary human bone marrow (BM) stromal cells

Design

Preclinical

Authors

RSRanita SungaranServices AustraliaOCOrin ChisholmThe University of SydneyBMBoban MarkovicThe University of Sydney

Discussion

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Implication

Alpha-granule proteins may regulate TPO expression via stromal cells; leaves open any role in physiologic or pathologic thrombopoiesis.

Structured PICO

P
Population
Primary human bone marrow (BM) stromal cells
I
Intervention
Platelet alpha-granular proteins (PDGF BB, FGF 2, PF4, TSP, TGF-beta, whole-platelet lysate)
O
Outcome
Thrombopoietin (TPO) mRNA expressionsurrogate

Platelet alpha-granular proteins regulate TPO gene expression in bone marrow stromal cells, suggesting a feedback mechanism for platelet production.

Cite This Study

Sungaran et al. (2000) studied this question.

synapsesocial.com/papers/6a8971d1abe412682d92e3d4https://doi.org/10.1182/blood.v95.10.3094
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Murine thrombopoietin mRNA levels are modulated by platelet count1995 · 200 citations
  2. 2Platelet Factor 4: Production, Structure, and Physiologic and Immunologic Action1991 · 169 citations
  3. 3A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders1996 · 207 citations
  4. 4Carboxy‐terminal peptides (C1–24 and C13–24 but not C1–13) of platelet factor 4 inhibit murine megakaryocytopoiesis, an activity which is neutralized by heparin1996 · 16 citations
  5. 5Stromal Cells in Haemopoiesis2007 · 86 citations