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September 1, 1978Acta Pathologica Microbiologica Scandinavica Section B Microbiology

Experimental Endocarditis in Rabbits

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Population

34 rabbits with sterile endocarditis induced by insertion of a polyethylene catheter in the left side of the…

Design

Preclinical

Authors

EGErnö GutschikSociedad Española de CardiologíaNCNils ChristensenTechnische Universität Braunschweig

Discussion

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Implication

Enables catheter-free rabbit endocarditis models; leaves open translation to human pathophysiology and antibiotic studies.

Structured PICO

P
Population
34 rabbits with sterile endocarditis induced by insertion of a polyethylene catheter in the left side of the heart
I
Intervention
Injection of approximately 10(8) Streptococcus faecalis into the blood stream simultaneous with the removal of the catheter which had been in place for 3 days
O
Outcome
Course of bacterial endocarditis (vegetation growth, bacterial density, secondary spreading, and extracardial manifestations) assessed by autopsysurrogate

This experimentally provoked bacterial endocarditis in rabbits provides a good imitation of human subacute endocarditis, suitable for studying pathophysiology and antibiotic efficacy.

Cite This Study

Gutschik et al. (1978) studied this question.

synapsesocial.com/papers/6a89733340fe6a3effcb09behttps://doi.org/10.1111/j.1699-0463.1978.tb00035.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antimicrobial Therapy of Experimental Enterococcal Endocarditis1975 · 70 citations
  2. 2Experimental Endocarditis Due to Pseudomonas aeruginosa. I. Description of a Model1976 · 57 citations
  3. 3Cephalosporin-Aminoglycoside Synergism in Experimental Enterococcal Endocarditis1976 · 21 citations
  4. 4Effect of Combinations of Penicillin and Aminoglycosides on Streptococcus faecalis: A Comparative Study of Seven Aminoglycoside Antibiotics1977 · 31 citations