Why the study?
Does chronic pentolinium therapy affect blood pressure and cardiac output in hypertensive patients?
Does chronic pentolinium therapy affect blood pressure and cardiac output in hypertensive patients?
Chronic pentolinium therapy lowers blood pressure in hypertensive patients primarily by reducing cardiac output, highlighting the role of ganglionic blockade on venoconstrictor tone.
Should not change hypertension management; hypothesis-generating for venoconstrictor tone in seated BP control.
Using a tracer injection technic, modified to provide accurate and repeated determinations of cardiac output in the ambulatory patient, the authors have shown that chronic pentolinium therapy for hypertension lowers blood pressure by reducing cardiac output in the seated position. From these observations and the work of others, they believe that the effect of ganglionic blockade on venoconstrictor tone deserves greater emphasis.
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Smith et al. (1956) studied this question.
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