Why the study?
Does pentolinium tartrate with and without hydralazine lower blood pressure in patients with severe hypertension?
Does pentolinium tartrate with and without hydralazine lower blood pressure in patients with severe hypertension?
Pentolinium tartrate, an autonomic blocking agent, has been used to lower blood pressure in severe hypertension, potentially in combination with hydralazine.
Answers are grounded in this paper and cite their sources.
Leaves open pentolinium tartrate utility in severe hypertension; prospective trials needed before any clinical role with or without hydralazine.
PENTOLINIUM tartrate is a pentamethonium derivative in which the two terminal quaternary nitrogen atoms are included in a pyrrolidine ring rather than each being trimethylated: This substance is an autonomiC blocking agent like its parent methonium compound. It is longer acting and has greater absolute effect on blood pressure, coupled with a relatively smaller effect on gastrointestinal motility, than the hexamethonium ion.1 2 3 Pentolinium tartrate has been used alone to lower blood pressure and thereby to permit regression of the signs and symptoms associated with severe hypertension.4 5 6 For the malignant phase of hypertension, with its poor prognosis,7 8 9 the combination of hydralazine . . .
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Perry et al. (1955) studied this question.
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