Key result
Polyurethane-based biomaterials demonstrated thermomechanical properties suitable for cardiovascular applications, particularly for annuloplastic rings in mitral valve repair.
Novel biostable polyurethane formulations demonstrate promising thermomechanical properties for use in cardiovascular devices such as annuloplastic rings for mitral valve repair.
Supports preclinical device development for mitral repair; leaves open human translation pending in vivo validation.
A series of biostable polyurethane (PUR) formulations, including a composite containing a clay as filler, were prepared as new biomaterials for cardiovascular applications. Poly(dimethyl siloxane) and poly(tetramethylene oxide) were selected as macrodiols because of their mechanical properties and the high hydrolysis resistance they confer to PURs. 1,6‐Diisocyanatohexane and 1,4‐cyclohexane dimethanol were used as a diisocyanate and chain extender, respectively. The polymeric products were chemically, thermally, and mechanically characterized. Thermomechanical characterizations highlighted that some of the obtained formulations are promising materials for applications in the cardiovascular field, in particular, for the realization of annuloplastic rings in mitral valve repair.
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Silvestri et al. (2011) studied Cardiovascular applications (mitral valve repair). Polyurethane-based biomaterials was evaluated on Thermomechanical properties. Polyurethane-based biomaterials demonstrated thermomechanical properties suitable for cardiovascular applications, particularly for annuloplastic rings in mitral valve repair.
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