Key result
The LumipulsePresto hs-cTnI assay demonstrated high diagnostic accuracy for acute myocardial infarction, comparable to the established hs-cTnT assay (AUC 0.89 vs 0.89; P=0.82).
Why the study?
Assays based on the 0-hour/1-hour algorithm using hs-cTn are currently limited to a few specific platforms, prompting evaluation of the new LumipulsePresto hs-cTnI assay for AMI diagnosis.
Does a novel high-sensitivity cardiac troponin I assay provide comparable diagnostic accuracy to established high-sensitivity cardiac troponin T assays for acute myocardial infarction in patients with suspected NSTEMI?
Population
442 patients with suspected non-ST-elevation myocardial infarction across three hospitals in Japan and Taiwan
Comparison
LumipulsePresto hs-cTnI vs serial Roche-Elecsys hs-cTnT
Design
Prospective cohort study
Follow-up
30-day
Authors
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May support novel hs-cTnI assay use in suspected NSTEMI; leaves open outcome impact in 0/1-hour algorithms.
Cohort (n=442)
Yes
Does a novel high-sensitivity cardiac troponin I assay provide comparable diagnostic accuracy to established high-sensitivity cardiac troponin T assays for acute myocardial infarction in patients with suspected NSTEMI?
Effect estimate: AUC 0.89 (95% CI 0.86-0.93)
Absolute Event Rate: 0.89% vs 0.89%
p-value: p=0.82
The novel high-sensitivity cardiac troponin I assay demonstrates high diagnostic accuracy for acute myocardial infarction, comparable to established assays, supporting its clinical utility in a 0-/1-hour rule-out algorithm.
Shiozaki et al. (2021) conducted a cohort in Suspected non-ST-elevation myocardial infarction (n=442). LumipulsePresto hs-cTnI assay vs. hs-cTnT (Roche-Elecsys) was evaluated on Diagnostic accuracy for acute myocardial infarction (AUC) (AUC 0.89, 95% CI 0.86-0.93, p=0.82). The LumipulsePresto hs-cTnI assay demonstrated high diagnostic accuracy for acute myocardial infarction, comparable to the established hs-cTnT assay (AUC 0.89 vs 0.89; P=0.82).
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