Neurohypophysial or hypothalamic tissue, in combination with a sympathetic amine, increases significantly the release of adrenocorticotrophic hormone (ACTH) from rat anterior-pituitary tissue in vitro (Saffran & Schally, 1955a). A corticotro- phin-releasing factor (CRF) was detected in posterior-pituitary extracts and was shown to be distinct from oxytocin, vasopressin and histamine (Saffran, Schally & Benfey, 1955; Schaily & Saffran, 1956). The active material has now been concentrated several thousand-fold by serial paper chromatography and the amino acids present in an acid hydrolysate of a concentrate have been identified.
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Schally et al. (1958) studied this question.
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