July 16, 1981Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Embryonic growth and innervation of rat skeletal muscles I. neural regulation of muscle fibre numbers

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Population

Rat embryos

Comparison

Tetrodotoxin via slow-release capsules or… vs Normal control embryos

Design

Preclinical

Authors

AHAJ HarrisJohn Innes Centre

Discussion

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Implication

Animal data distinguish myotube pathways; leaves open translation to human congenital myopathies.

Structured PICO

Population

Rat embryos

Intervention

Tetrodotoxin (TTX) via slow-release capsules or P-bungarotoxin (P-BTX) injections in utero

Comparator

Normal control embryos

Outcome

Number of muscle units and development of primary and secondary myotubessurrogate

This study demonstrates that while primary myotube development is autonomous, secondary myotube formation requires both innervation and muscle contraction.

Cite This Study

AJ Harris (1981) studied this question.

synapsesocial.com/papers/6a897ca6851416c68bf7d034 https://doi.org/10.1098/rstb.1981.0076

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Embryonic growth and innervation of rat skeletal muscles I. neural regulation of muscle fibre numbers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Embryonic growth and innervation of rat skeletal muscles I. neural regulation of muscle fibre numbers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider