What does this research mean for the field?

Impaired right atrial reservoir strain is independently associated with the progression of tricuspid regurgitation in atrial fibrillation patients with initially insignificant tricuspid regurgitation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine whether right atrial functional remodeling, assessed by reservoir strain, independently predicts the progression of tricuspid regurgitation in patients with atrial fibrillation.

August 22, 2026Heart and Vessels

Right atrial reservoir strain < 12.6% linked to significant TR progression in AF patients.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Atrial fibrillation (n=484). Intervention: Right atrial reservoir strain < 12.6% vs. Right atrial reservoir strain ≥ 12.6%. Primary outcome: Progression to significant (at least moderate) tricuspid regurgitation (p=0.027).

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Why the study?

Although right atrial structural remodeling contributes to tricuspid regurgitation progression in AF, the impact of right atrial functional remodeling on progression remained unclear.

Does impaired right atrial reservoir strain predict tricuspid regurgitation progression in patients with atrial fibrillation?

Population

484 AF patients with insignificant TR at baseline

Comparison

RA reservoir strain < 12.6% vs >= 12.6%

Design

Cohort study

Follow-up

Mean 3.6 +- 2.7 years

Key result

Right atrial reservoir strain < 12.6% was independently associated with progression to significant tricuspid regurgitation in patients with atrial fibrillation (p=0.027).

Authors

DKDae-Young Kim KLKi Jeung Lee SRSung Kee Ryu

Discussion

Member takes

Overview

Impaired RA function may flag AF patients for closer TR surveillance; leaves open whether RA-focused strategies alter progression.

Key Points

To determine whether right atrial functional remodeling, assessed by reservoir strain, independently predicts the progression of tricuspid regurgitation in patients with atrial fibrillation.
Analyzed 484 patients with atrial fibrillation (mean age 68 ± 12 years, 38% female) and baseline insignificant tricuspid regurgitation over a mean follow-up of 3.6 ± 2.7 years.
Excluded patients with prior cardiac surgery, implantable electronic devices, moderate or greater valvular disease, LVEF < 50%, or follow-up under 6 months.
Determined an optimal cut-off value of 12.6% for right atrial reservoir strain using receiver operating characteristic analysis.
Significant tricuspid regurgitation developed in 46 patients (9.5%) during follow-up.
Patients with right atrial reservoir strain < 12.6% were older, had higher rates of persistent atrial fibrillation, elevated pulmonary artery systolic pressure, and larger atrial volumes.
Right atrial reservoir strain < 12.6% was independently associated with tricuspid regurgitation progression after adjusting for age, sex, and right atrial volume (p = 0.027), remaining significant after adjustment for E/e' or pulmonary artery systolic pressure.

Study Design

Type

Cohort (n=484)

Structured PICO

Does impaired right atrial reservoir strain predict tricuspid regurgitation progression in patients with atrial fibrillation?

Population

484 patients (mean age 68 years, 38% female) with atrial fibrillation and insignificant baseline tricuspid regurgitation, followed for a mean of 3.6 years.

Exposure

Right atrial (RA) reservoir strain assessment (cut-off < 12.6%)

Outcome

Progression to significant (at least moderate) tricuspid regurgitationsurrogate

Main Result

p-value: p=0.027

Impaired right atrial reservoir strain (<12.6%) independently predicts the progression to significant tricuspid regurgitation in patients with atrial fibrillation, providing complementary prognostic information to structural remodeling.

Cite This Study

Kim et al. (2026) conducted a cohort in Atrial fibrillation (n=484). Right atrial reservoir strain < 12.6% vs. Right atrial reservoir strain ≥ 12.6% was evaluated on Progression to significant (at least moderate) tricuspid regurgitation (p=0.027). Right atrial reservoir strain < 12.6% was independently associated with progression to significant tricuspid regurgitation in patients with atrial fibrillation (p=0.027).

synapsesocial.com/papers/6a8982e6ca7ade938187f3de https://doi.org/10.1007/s00380-026-02747-3

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August 22, 2026Heart and Vessels

Right atrial reservoir strain < 12.6% linked to significant TR progression in AF patients.

View Full Paper

Ask AI

Bookmark

Why the study?

Although right atrial structural remodeling contributes to tricuspid regurgitation progression in AF, the impact of right atrial functional remodeling on progression remained unclear.

Does impaired right atrial reservoir strain predict tricuspid regurgitation progression in patients with atrial fibrillation?

Population

484 AF patients with insignificant TR at baseline

Comparison

RA reservoir strain < 12.6% vs >= 12.6%

Design

Cohort study

Follow-up

Mean 3.6 +- 2.7 years

Key result

Right atrial reservoir strain < 12.6% was independently associated with progression to significant tricuspid regurgitation in patients with atrial fibrillation (p=0.027).

Authors

DKDae-Young Kim KLKi Jeung Lee SRSung Kee Ryu

Discussion

Member takes

Overview

Impaired RA function may flag AF patients for closer TR surveillance; leaves open whether RA-focused strategies alter progression.

Key Points

To determine whether right atrial functional remodeling, assessed by reservoir strain, independently predicts the progression of tricuspid regurgitation in patients with atrial fibrillation.
Analyzed 484 patients with atrial fibrillation (mean age 68 ± 12 years, 38% female) and baseline insignificant tricuspid regurgitation over a mean follow-up of 3.6 ± 2.7 years.
Excluded patients with prior cardiac surgery, implantable electronic devices, moderate or greater valvular disease, LVEF < 50%, or follow-up under 6 months.
Determined an optimal cut-off value of 12.6% for right atrial reservoir strain using receiver operating characteristic analysis.
Significant tricuspid regurgitation developed in 46 patients (9.5%) during follow-up.
Patients with right atrial reservoir strain < 12.6% were older, had higher rates of persistent atrial fibrillation, elevated pulmonary artery systolic pressure, and larger atrial volumes.
Right atrial reservoir strain < 12.6% was independently associated with tricuspid regurgitation progression after adjusting for age, sex, and right atrial volume (p = 0.027), remaining significant after adjustment for E/e' or pulmonary artery systolic pressure.

Study Design

Type

Cohort (n=484)

Structured PICO

Does impaired right atrial reservoir strain predict tricuspid regurgitation progression in patients with atrial fibrillation?

Population

484 patients (mean age 68 years, 38% female) with atrial fibrillation and insignificant baseline tricuspid regurgitation, followed for a mean of 3.6 years.

Exposure

Right atrial (RA) reservoir strain assessment (cut-off < 12.6%)

Outcome

Progression to significant (at least moderate) tricuspid regurgitationsurrogate

Main Result

p-value: p=0.027

Cite This Study

synapsesocial.com/papers/6a8982e6ca7ade938187f3de https://doi.org/10.1007/s00380-026-02747-3

Also Consider

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