June 6, 2025Frontiers in Cardiovascular MedicineOpen Access

Left atrial pressure and significant tricuspid regurgitation in persistent atrial fibrillation

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Persistent atrial fibrillation (n=189). Intervention: Elevated left atrial systolic pressure (LASP) vs. Lower left atrial systolic pressure. Primary outcome: Moderate-to-severe tricuspid regurgitation (OR 1.53, 95% CI 1.18-2.01, p=0.002).

View Full Paper

Ask AI

Bookmark

Key result

Elevated left atrial systolic pressure independently predicted moderate-to-severe tricuspid regurgitation in patients with persistent atrial fibrillation (OR 1.53 per 1-unit increase).

Why the study?

AF contributes to isolated TR, with elevated LAP playing a key role in progression and outcomes, motivating investigation of the relationship between LAP and TR in AF.

Population

189 patients with AF undergoing LA appendage closure at two centers in China

Comparison

Moderate-to-severe TR vs no significant TR

Design

Two-center observational study

Authors

MYMaolin Ye YQYan Qiu DLDawei Lin

Discussion

Member takes

Overview

Should not yet change tricuspid regurgitation management in AF; leaves open causal roles and need for prospective validation.

Study Design

Type

Cross-Sectional (n=189)

Multicenter

Yes

Structured PICO

Population

189 patients with persistent atrial fibrillation undergoing left atrial appendage closure, retrospectively analyzed to assess the relationship between left atrial pressure and tricuspid regurgitation.

Outcome

Predictors of significant (moderate-to-severe) tricuspid regurgitation, including left atrial pressure (LAP) and echocardiographic parameters of right heart remodeling.surrogate

Main Result

Odds Ratio: 1.53 (95% CI 1.18–2.01)

p-value: p=0.002

Limitations

Observational, retrospective, and cross-sectional design limits the ability to establish causality
Extended enrollment period may introduce variability in clinical practice and imaging techniques
Lack of detailed data on the severity of atrial fibrillation burden
Left atrial size was assessed using anteroposterior diameter rather than volume
Tricuspid regurgitation severity was assessed using regurgitant jet area rather than quantitative parameters like effective regurgitant orifice area
Small sample size limited granular classification of tricuspid regurgitation severity
Single-center, observational, retrospective, and cross-sectional study design limiting causal inference
Extended enrollment period introducing variability in clinical practice and imaging techniques
Lack of detailed data on the severity of AF burden
LA size assessed using anteroposterior diameter rather than LA volume
Lack of dedicated echocardiography specialists for standardized imaging analysis
TR severity assessed using regurgitant jet area rather than quantitative parameters like effective regurgitant orifice area (EROA)
Binary categorization of TR due to limited sample size

Cite This Study

Ye et al. (2025) conducted a cross-sectional in Persistent atrial fibrillation (n=189). Elevated left atrial systolic pressure (LASP) vs. Lower left atrial systolic pressure was evaluated on Moderate-to-severe tricuspid regurgitation (OR 1.53, 95% CI 1.18-2.01, p=0.002). Elevated left atrial systolic pressure independently predicted moderate-to-severe tricuspid regurgitation in patients with persistent atrial fibrillation (OR 1.53 per 1-unit increase).

synapsesocial.com/papers/6a818154d7cc3676436639bf https://doi.org/10.3389/fcvm.2025.1575750

View Full Paper

Ask AI

Bookmark

June 6, 2025Frontiers in Cardiovascular MedicineOpen Access

Left atrial pressure and significant tricuspid regurgitation in persistent atrial fibrillation

View Full Paper

Ask AI

Bookmark

Key result

Elevated left atrial systolic pressure independently predicted moderate-to-severe tricuspid regurgitation in patients with persistent atrial fibrillation (OR 1.53 per 1-unit increase).

Why the study?

AF contributes to isolated TR, with elevated LAP playing a key role in progression and outcomes, motivating investigation of the relationship between LAP and TR in AF.

Population

189 patients with AF undergoing LA appendage closure at two centers in China

Comparison

Moderate-to-severe TR vs no significant TR

Design

Two-center observational study

Authors

MYMaolin Ye YQYan Qiu DLDawei Lin

Discussion

Member takes

Overview

Should not yet change tricuspid regurgitation management in AF; leaves open causal roles and need for prospective validation.

Study Design

Type

Cross-Sectional (n=189)

Multicenter

Yes

Structured PICO

Population

Outcome

Predictors of significant (moderate-to-severe) tricuspid regurgitation, including left atrial pressure (LAP) and echocardiographic parameters of right heart remodeling.surrogate

Main Result

Odds Ratio: 1.53 (95% CI 1.18–2.01)

p-value: p=0.002

Limitations

Observational, retrospective, and cross-sectional design limits the ability to establish causality
Extended enrollment period may introduce variability in clinical practice and imaging techniques
Lack of detailed data on the severity of atrial fibrillation burden
Left atrial size was assessed using anteroposterior diameter rather than volume
Tricuspid regurgitation severity was assessed using regurgitant jet area rather than quantitative parameters like effective regurgitant orifice area
Small sample size limited granular classification of tricuspid regurgitation severity
Single-center, observational, retrospective, and cross-sectional study design limiting causal inference
Extended enrollment period introducing variability in clinical practice and imaging techniques
Lack of detailed data on the severity of AF burden
LA size assessed using anteroposterior diameter rather than LA volume
Lack of dedicated echocardiography specialists for standardized imaging analysis
TR severity assessed using regurgitant jet area rather than quantitative parameters like effective regurgitant orifice area (EROA)
Binary categorization of TR due to limited sample size

Cite This Study

synapsesocial.com/papers/6a818154d7cc3676436639bf https://doi.org/10.3389/fcvm.2025.1575750

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark