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December 20, 2022Frontiers in Cardiovascular MedicineOpen Access

Incidence of atrial functional tricuspid regurgitation and its correlation with tricuspid valvular deformation in patients with persistent atrial fibrillation

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Key result

Tricuspid annulus diameter was independently associated with significant tricuspid regurgitation in patients with persistent atrial fibrillation (OR 1.1 per mm), with a BSA-indexed cutoff of 23 mm/m2 providing the best predictive value.

Why the study?

With the growing prevalence of AF, concomitant atrial functional tricuspid regurgitation is increasing, but its incidence and association with tricuspid valvular deformation in persistent AF remained to be elucidated.

Population

344 patients with persistent AF undergoing 2-dimensional echocardiography

Comparison

Significant TR (≥ moderate) vs non-significant TR

Design

Retrospective study

Authors

YYYuko YamamotoHaradoi HospitalMDMasao DaimonCardiac ImagingKNKoki NakanishiCardiac Imaging

Discussion

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Member takes

Overview

Significant atrial FTR affects ~25% of persistent AF patients; leaves open whether TA dilatation drives progression.

Study Design

Type

Cross-Sectional (n=344)

Multicenter

No

Structured PICO

P
Population
344 patients (mean age 73 years, 27.6% female) with persistent atrial fibrillation and preserved left ventricular ejection fraction, evaluated retrospectively for tricuspid regurgitation.
O
Outcome
Incidence of significant atrial functional tricuspid regurgitation (moderate or greater) and its association with tricuspid valvular deformation (tricuspid annulus diameter, tethering height, and area)surrogate

Main Result

Odds Ratio: 1.1 (95% CI 1.01–1.26)

p-value: p=0.03

In patients with persistent atrial fibrillation without left heart disease, nearly 25% have significant functional tricuspid regurgitation, which is strongly associated with BSA-corrected tricuspid annular dilation.

Limitations

  • Single-center, observational, retrospective, cross-sectional study design limits causal inference and introduces potential selection bias.
  • Lack of longitudinal follow-up data for many patients.
  • Severity of atrial fibrillation burden was not uniformly available.
  • Potential inclusion of patients with mild pulmonary hypertension or left ventricular diastolic dysfunction.
  • Reliance on 2-dimensional echocardiography, which has limitations in assessing complex 3-dimensional right ventricular and tricuspid valve geometry.
  • single-center, observational, retrospective, cross-sectional study
  • selection bias cannot be ruled out
  • causality cannot be established
  • limited number of patients to follow
  • severity of AF burden was not uniformly available

Cite This Study

Yamamoto et al. (2022) conducted a cross-sectional in Persistent atrial fibrillation (n=344). Tricuspid annulus diameter was evaluated on Presence of significant (≥ moderate) tricuspid regurgitation (OR 1.1, 95% CI 1.01-1.26, p=0.03). Tricuspid annulus diameter was independently associated with significant tricuspid regurgitation in patients with persistent atrial fibrillation (OR 1.1 per mm), with a BSA-indexed cutoff of 23 mm/m2 providing the best predictive value.

synapsesocial.com/papers/6a86eeb7a810ea404bcf94e0https://doi.org/10.3389/fcvm.2022.1023732
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tricuspid valve geometry and right heart remodelling: insights into the mechanism of atrial functional tricuspid regurgitation2020 · 66 citations
  2. 2Tricuspid Valve Tethering Predicts Residual Tricuspid Regurgitation After Tricuspid Annuloplasty2005 · 335 citations
  3. 3Comparison of 2-Dimensional, 3-Dimensional, and Surgical Measurements of the Tricuspid Annulus Size2015 · 100 citations
  4. 4Geometric Determinants of Functional Tricuspid Regurgitation2006 · 357 citations
  5. 5JCS/JSCS/JATS/JSVS 2020 Guidelines on the Management of Valvular Heart Disease2020 · 371 citations