Key result
Shock induces catecholamine resistance via adrenoceptor desensitization, highlighting the need for catecholamine-sparing strategies.
This review summarizes cardiovascular adrenoceptor physiology, shock-induced alterations such as desensitization, and potential therapeutic strategies to restore adrenergic responsiveness in patients with shock.
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Jozwiak et al. (2026) conducted a review in Shock. Shock induces adrenoceptor desensitization and impaired downstream signaling, leading to catecholamine resistance and highlighting the potential need for catecholamine-sparing strategies.
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