HFA-PEFF and H2FPEF scores for cardiovascular risk stratification in patients with sick sinus syndrome

Q: What are the key findings of this study?

The HFA-PEFF score significantly predicted the primary endpoint in patients with sick sinus syndrome, demonstrating an area under the curve of 0.70.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Sick Sinus Syndrome (n=206). Intervention: HFA-PEFF score vs. Lower HFA-PEFF score. Primary outcome: Primary endpoint (AUC 0.70, 95% CI 0.60-0.79, p=<0.001).

Q: What question did this study set out to answer?

To evaluate the utility of the HFA-PEFF and H2FPEF scores for cardiovascular risk stratification and predicting adverse outcomes in patients with sick sinus syndrome.

Hironobu Sumiyoshi; Hidemori Hayashi; Akira Nakashima; Kenta Yoshida; T Kono; Maki Ono; Akira Mizukami; Tohru Minamino; Hiroshi Tasaka

doi:10.1007/s00380-026-02750-8

August 19, 2026Heart and Vessels

HFA-PEFF and H2FPEF scores for cardiovascular risk stratification in patients with sick sinus syndrome

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Key result

HFA-PEFF score predicts major events in sick sinus syndrome with ~0.70 AUC.

AUC 0.70
95% CI 0.60-0.79
P<0.001
n=206

Why the study?

Does the HFA-PEFF score predict cardiovascular events and persistent atrial fibrillation in patients with sick sinus syndrome?

Key Points

To evaluate the utility of the HFA-PEFF and H2FPEF scores for cardiovascular risk stratification and predicting adverse outcomes in patients with sick sinus syndrome.
Multicenter study evaluating a total cohort of 206 patients with sick sinus syndrome across three medical centers.
Patients were stratified based on heart failure risk scores, including HFA-PEFF (scores 0–4, n=112 vs 5–6, n=94) and H2FPEF (scores 0–5, n=150 vs 6–9, n=56).
Echocardiographic parameters, laboratory findings, device programming characteristics, and clinical outcomes were analyzed during follow-up.
In the total cohort of 206 patients, persistent AF occurred in 45 (21.8%) and primary endpoint events occurred in 35 patients.
In patients without prior hospitalization for heart failure, an HFA-PEFF score ≥ 5 was significantly associated with primary endpoint incidence (P = 0.028 by log-rank test) and persistent AF (P = 0.010 by log-rank test).

Study Design

Type

Observational (n=206)

Multicenter

Yes

Structured PICO

Does the HFA-PEFF score predict cardiovascular events and persistent atrial fibrillation in patients with sick sinus syndrome?

P

Population

206 patients with sick sinus syndrome (median age 81, 49.5% female) evaluated across three centers in Japan for cardiovascular risk stratification.

E

Exposure

HFA-PEFF and H2FPEF scores for cardiovascular risk stratification

O

Outcome

Primary endpoint (definition not explicitly stated in the provided text)

Main Result

Effect estimate: AUC 0.70 (95% CI 0.60-0.79)

p-value: p=<0.001

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Implication

The HFA-PEFF score can be used for cardiovascular risk stratification and predicting persistent atrial fibrillation in patients with sick sinus syndrome.

Abstract

The HFA-PEFF and H

Discussion

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Cite This Study

Sumiyoshi et al. (2026) conducted an observational in Sick Sinus Syndrome (n=206). HFA-PEFF score vs. Lower HFA-PEFF score was evaluated on Primary endpoint (AUC 0.70, 95% CI 0.60-0.79, p=<0.001). The HFA-PEFF score significantly predicted the primary endpoint in patients with sick sinus syndrome, demonstrating an area under the curve of 0.70.

synapsesocial.com/papers/6a898315ca7ade938187f3e5 https://doi.org/10.1007/s00380-026-02750-8

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HFA-PEFF and H2FPEF scores for cardiovascular risk stratification in patients with sick sinus syndrome

Key Points

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

HFA-PEFF and H2FPEF scores for cardiovascular risk stratification in patients with sick sinus syndrome

Key Points

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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