Key result
Pediatric trials of antihypertensive agents are more likely to succeed when utilizing weight-based dosing, liquid formulations, appropriate dose ranges, and suitable blood pressure endpoints.
Population
Pediatric patients with hypertension
Design
Review
Authors
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May guide future pediatric antihypertensive trial designs; leaves open effects on approvals and clinical outcomes.
Optimizing trial design with weight-based dosing, liquid formulations, and appropriate endpoints improves the success rate of pediatric antihypertensive trials.
Hill et al. (2014) conducted a review in Pediatric hypertension. Antihypertensive agents was evaluated. Pediatric trials of antihypertensive agents are more likely to succeed when utilizing weight-based dosing, liquid formulations, appropriate dose ranges, and suitable blood pressure endpoints.
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