Sequential Changes in Autonomic Regulation of Cardiac Myocytes after In Vivo Endotoxin Injection in Rat
Population
Rats (anesthetized and conscious, chronically instrumented) and isolated cardiac myocytes
Comparison
In vivo endotoxin (EDTX) injection (6 mg/kg) vs Control (no EDTX injection)
Design
Preclinical
Follow-up
36 hours
Authors
Discussion
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Member takes
Implication
May inform septic cardiomyopathy mechanisms in animals; leaves open translation to human autonomic regulation of I(Ca).
Structured PICO
P
Population
Rats (anesthetized and conscious, chronically instrumented) and isolated cardiac myocytes
I
Intervention
In vivo endotoxin (EDTX) injection (6 mg/kg)
C
Comparator
Control (no EDTX injection)
O
Outcome
L-type calcium current (I(Ca)) density and its autonomic regulationsurrogate
Time-dependent changes in the adenylyl cyclase pathway in cardiac myocytes may contribute to myocardial dysfunction during sepsis via autonomic regulation of L-type calcium currents.
Cite This Study
Abi‐Gerges et al. (1999) studied this question.