Prognostic Significance of Elevated Cardiac Troponin-T Levels in Acute Respiratory Distress Syndrome Patients
Key result
Increasing cardiac troponin T levels in patients with Acute Respiratory Distress Syndrome are significantly associated with increased 60-day mortality (adjusted HR 1.45 per 1 ng/mL increase).
Why the study?
Do elevated cardiac troponin T levels predict increased 60-day mortality in patients with ARDS?
Population
177 patients with Acute Respiratory Distress Syndrome (ARDS) at a tertiary-care academic medical center
Comparison
Elevated cardiac troponin T levels measured… vs Lower or undetectable cTnT levels
Design
Cohort
Follow-up
60 days
Authors
Discussion
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Member takes
Implication
May aid ARDS mortality risk stratification; leaves open whether troponin identifies modifiable pathways or warrants intervention.
Study Design
Type
Cohort (n=177)
Multicenter
No
Structured PICO
Do elevated cardiac troponin T levels predict increased 60-day mortality in patients with ARDS?
P
Population
177 adult intensive care unit patients with Acute Respiratory Distress Syndrome, followed for 60 days to assess the prognostic value of cardiac biomarkers.
E
Exposure
Elevated cardiac troponin T (cTnT) levels measured within 48 hours of ARDS onset
C
Comparator
Lower or undetectable cTnT levels
O
Outcome
60-day mortalityhard clinical
Main Result
Hazard Ratio: 1.45 (95% CI 1.17–1.81)
p-value: p=0.001
Elevated cardiac troponin T levels are common in ARDS patients and independently predict increased 60-day mortality and worse clinical outcomes, despite no association with ECG evidence of coronary ischemia.
Limitations
- Single-center study design limits generalizability to other populations.
- Echocardiographic and ECG results were only available for a portion of the study patients, introducing potential selection bias.
- Small numbers of echocardiograms and electrocardiograms available for analysis limited statistical power.
- Inability to capture serial echocardiograms or serial cTnT measurements over time.
Cite This Study
Rivara et al. (2012) conducted a cohort in Acute Respiratory Distress Syndrome (ARDS) (n=177). Elevated cardiac troponin T (cTnT) levels vs. Lower or undetectable cTnT levels was evaluated on 60-day mortality (HR 1.45, 95% CI 1.17-1.81, p=0.001). Increasing cardiac troponin T levels in patients with Acute Respiratory Distress Syndrome are significantly associated with increased 60-day mortality (adjusted HR 1.45 per 1 ng/mL increase).