November 1, 2007Critical Care Medicine
Biomarker evidence of myocardial cell injury is associated with mortality in acute respiratory distress syndrome*
Key result
Elevated cardiac markers in patients with acute respiratory distress syndrome were associated with significantly higher 60-day mortality (p=0.01) and increased organ failure (p=0.02).
Why the study?
Are elevated cardiac markers associated with increased mortality and organ failure in patients with acute respiratory distress syndrome?
Population
305 subjects with acute respiratory distress syndrome enrolled in a prospective intensive care unit cohort
Comparison
Elevated cardiac markers vs Normal cardiac markers
Design
Cohort
Follow-up
60 days
Authors
Discussion
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Member takes
Implication
May refine ARDS prognostication; hypothesis-generating and requires prospective validation before practice change.
Study Design
Type
Cohort (n=305)
Multicenter
No
Structured PICO
Are elevated cardiac markers associated with increased mortality and organ failure in patients with acute respiratory distress syndrome?
P
Population
305 patients with acute respiratory distress syndrome in an intensive care unit cohort, evaluated for the association of cardiac biomarkers with 60-day mortality and organ failure.
E
Exposure
Elevated cardiac markers (troponin and creatine phosphokinase isoenzyme levels)
C
Comparator
Normal cardiac markers
O
Outcome
60-day mortality and organ failurehard clinical
Main Result
p-value: p=0.01
Elevated cardiac biomarkers in ARDS patients are independently associated with increased 60-day mortality and organ failure, particularly in those with lower baseline severity of illness.
Cite This Study
Bajwa et al. (2007) conducted a cohort in Acute respiratory distress syndrome (n=305). Elevated cardiac markers (troponin and creatine phosphokinase isoenzyme) vs. Normal cardiac marker levels was evaluated on Mortality and organ failure (p=0.01). Elevated cardiac markers in patients with acute respiratory distress syndrome were associated with significantly higher 60-day mortality (p=0.01) and increased organ failure (p=0.02).