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No mortality benefit from pulmonary-artery catheter-guided therapy in high-risk surgical patients; challenges observational harm signals and leaves routine use unproven.
▴ Sandham JD, Hull RD, Brant RF, et al for the Canadian Critical Care Clinical Trials Group. A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients. N Engl J Med2003;348:5–14 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Recent observational studies suggest that the use of pulmonary artery catheters to guide treatment is associated with increased mortality. Outcomes have been confounded by the severity of the underlying illness. This multicentre, randomised, controlled clinical trial involving blinded assessment … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DSandham%26rft.auinit1%253DJ.%2BD.%26rft.volume%253D348%26rft.issue%253D1%26rft.spage%253D5%26rft.epage%253D14%26rft.atitle%253DA%2BRandomized%252C%2BControlled%2BTrial%2Bof%2Bthe%2BUse%2Bof%2BPulmonary-Artery%2BCatheters%2Bin%2BHigh-Risk%2BSurgical%2BPatients%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa021108%26rft_id%253Dinfo%253Apmid%252F12510037%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa021108&link_type=DOI [3]: /lookup/external-ref?access_num=12510037&link_type=MED&atom=%2Fthoraxjnl%2F58%2F3%2F236.atom [4]: /lookup/external-ref?access_num=000180134400002&link_type=ISI
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Terence Seemungal (2003) studied this question.
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