Key result
The nuclear membrane of rat cardiomyocytes contains inositol 1,4,5-trisphosphate receptors (384 ± 5 pS), LCC-like cation channels (209 ± 13 pS), and other ion channels with conductances ranging from 10 to 400 pS.
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Extends nuclear channel characterization in rat cardiomyocytes; leaves open relevance to human cardiac function.
Using the patch clamp technique in nucleus attached configuration we have found that the nuclear membrane of rat cardiomyocytes contains different types of ion channels with conductances in the range from 10 to 400 pS. In particular, we recorded inositol 1,4,5-trisphosphate receptors with conductance of 384 ± 5 pS and 209 ± 13 pS cation channels similar to LCC-channels, previously reported in neurons. In addition, we found at least two types of ion channels with significantly higher conductance than that of LCC-channels and several types of ion channels with lower conductance (10-90 pS).
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Kotyk et al. (2016) studied Healthy (animal model). Patch-clamp technique (nucleus attached configuration) was evaluated on Single-channel ion currents and conductances in the nuclear envelope. The nuclear membrane of rat cardiomyocytes contains inositol 1,4,5-trisphosphate receptors (384 ± 5 pS), LCC-like cation channels (209 ± 13 pS), and other ion channels with conductances ranging from 10 to 400 pS.
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