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July 1, 1985The Journal of General PhysiologyOpen Access

Slow currents through single sodium channels of the adult rat heart.

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Population

Ventricular cells dissociated from adult rat hearts

Design

Preclinical

Authors

JPJoseph B. PatlakMOM. Clara Ortíz

Discussion

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Overview

Challenges standard Na+ channel kinetic models; leaves open relevance to human ventricular arrhythmias.

Key Points

  • This research aims to investigate the characteristics of sodium currents through single channels in adult rat heart cells.
  • Utilized the patch-clamp technique to study Na+ channels from ventricular cells of adult rat hearts.
  • Measured conductance and inactivation properties at various holding potentials.
  • Examined effects of tetrodotoxin on channel activity and inactivation dynamics.
  • Conductance measured at 9.8 pS with a fast inactivation time constant of 1.7 ms at -40 mV.
  • Identified a slow inactivation component with a time constant between 8 and 14 ms, influenced by holding potential.
  • Occasional ultraslow currents lasting up to 150 ms were observed, indicating distinct functional modes of Na+ channels.

Structured PICO

P
Population
Ventricular cells dissociated from adult rat hearts
I
Intervention
Patch-clamp technique
O
Outcome
Currents through single Na+ channels (conductance, inactivation time constants)surrogate

Single sodium channels in adult rat ventricular cells exhibit slow inactivation currents due to repeated channel openings, suggesting multiple functional modes with distinct inactivation rates.

Cite This Study

Patlak et al. (1985) studied this question.

synapsesocial.com/papers/6a17b7eca0e670aec86ec016https://doi.org/10.1085/jgp.86.1.89
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