What is the clinical evidence from this study?

Study design: Other. Intervention: Glutaraldehyde or racemic DPI 201-106. Primary outcome: Single cardiac Na+ channel activity and open-time distribution.

What does this research mean for the field?

Spontaneously occurring and chemically induced non-inactivating cardiac Na+ channel activity share the same mechanism of inactivation failure characterized by burst-like openings and prolonged, voltage-dependent open states. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 22, 1987Proceedings of the Royal Society B Biological Sciences

Properties of normal and non-inactivating single cardiac Na+ channels

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Key result

Glutaraldehyde and DPI 201-106 induce repetitive cardiac Na+ channel openings mimicking spontaneous inactivation failure.

Why the study?

Properties and mechanisms of normal and non-inactivating single cardiac Na+ channels, including spontaneous and chemically induced modifications, were not fully characterized.

Population

Single cardiac Na+ channels from cultured neonatal rat heart cardiocytes

Comparison

Normal Na+ channel activity vs chemically induced modified Na+ channel activity

Design

Patch clamp study of inside-out patches at 19°C

Authors

MKM. KohlhardtJohannes Gutenberg University Mainz UFU. Fröbe JHJ. W. HerzigUniversity of Glasgow

Discussion

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Implication

Suggests Na+ channel heterogeneity in neonatal rat cells; leaves open relevance to adult human electrophysiology.

PICO

Intervention / Comparator

Glutaraldehyde or racemic DPI 201-106 (10-3 mol l-1 (glutaraldehyde) or 3 x 10-6 mol l-1 (DPI 201-106))

Primary Outcome

Single cardiac Na+ channel activity and open-time distribution

Cite This Study

Kohlhardt et al. (1987) studied this question. Glutaraldehyde or racemic DPI 201-106 was evaluated on Single cardiac Na+ channel activity and open-time distribution. Chemical modification with glutaraldehyde or DPI 201-106 induced repetitive Na+ channel activity similar to spontaneous failure of inactivation, characterized by prolonged open states.

synapsesocial.com/papers/6ac4aa594aa810f237fcd4de https://doi.org/10.1098/rspb.1987.0062

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Properties of normal and non-inactivating single cardiac Na+ channels

Discussion

Member takes

Implication

PICO

Cite This Study

Properties of normal and non-inactivating single cardiac Na+ channels

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider