Key result
Glucosamine treatment improved functional recovery following ischemia in isolated rat hearts, potentially mediated via the p38 MAPK pathway and increased O-GlcNAc levels.
Why the study?
Does glucosamine improve functional recovery following ischemia in isolated rat hearts?
Population
Isolated rat hearts
Comparison
Perfusion with 5 mM glucosamine vs Perfusion without glucosamine
Design
Preclinical
Follow-up
Up to 30 min of low-flow ischemia and 60 min of reperfusion
Authors
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Hypothesis-generating in isolated rat hearts; does not support clinical use and leaves mechanism open for translation.
Does glucosamine improve functional recovery following ischemia in isolated rat hearts?
Glucosamine-induced cardioprotection in isolated rat hearts may be mediated via the p38 MAPK pathway and increased O-GlcNAc levels.
Fülöp et al. (2007) studied Ischemia-reperfusion injury. Glucosamine vs. without glucosamine was evaluated on Functional recovery and kinase phosphorylation. Glucosamine treatment improved functional recovery following ischemia in isolated rat hearts, potentially mediated via the p38 MAPK pathway and increased O-GlcNAc levels.
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