Key result
Administration of glucosamine or PUGNAc during the first 20 minutes of reperfusion significantly improved cardiac functional recovery and reduced troponin release in isolated rat hearts.
Why the study?
Does administration of glucosamine or PUGNAc during reperfusion improve functional recovery and reduce troponin release in isolated rat hearts subjected to ischemia-reperfusion?
Population
Isolated perfused rat hearts subjected to 20 min of global, no-flow ischemia followed by 60 min of reperfusion
Comparison
Administration of glucosamine or PUGNAc during… vs Untreated control
Design
Preclinical
Follow-up
60 min of reperfusion
Authors
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Hypothesis-generating for O-GlcNAc modulation in reperfusion; leaves open translation to human cardioprotection.
Does administration of glucosamine or PUGNAc during reperfusion improve functional recovery and reduce troponin release in isolated rat hearts subjected to ischemia-reperfusion?
Increasing protein O-GlcNAc levels during reperfusion improves cardiac functional recovery and reduces calcium-mediated proteolysis in a rat model of ischemia-reperfusion.
Liu et al. (2007) studied Ischemia-reperfusion injury. Glucosamine or PUGNAc vs. Untreated control was evaluated on Cardiac functional recovery and troponin release. Administration of glucosamine or PUGNAc during the first 20 minutes of reperfusion significantly improved cardiac functional recovery and reduced troponin release in isolated rat hearts.
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