Why the study?
Does indomethacin reduce bone mineral content and bending strength in rabbits with tibial osteotomies?
Population
38 rabbits with tibial osteotomy fixed with a small metal plate
Comparison
Indomethacin 10 mg/kg/day vs Control group
Design
Preclinical
Follow-up
6 weeks
Authors
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May caution NSAID use during early fracture healing; leaves open translation to human osteotomies.
Does indomethacin reduce bone mineral content and bending strength in rabbits with tibial osteotomies?
Indomethacin administration retards bone healing and reduces bone strength in a rabbit osteotomy model, likely by inhibiting the early inflammatory reaction.
Keller et al. (1987) studied this question.
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