Key result
Indomethacin (10 mg/kg/day) improved valgus deformity in adolescent rabbits following bone bridge removal, whereas the deformity worsened in vehicle-treated controls (P = 0.004).
Why the study?
Does indomethacin improve valgus deformity in adolescent rabbits following epiphysiodesis?
Does indomethacin improve valgus deformity in adolescent rabbits following epiphysiodesis?
Indomethacin treatment for 21 days postoperatively improves valgus deformity in a rabbit model of epiphyseal plate closure.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating in rabbit physeal models; does not support clinical translation to adolescents.
The efficiency of indomethacin (10 mg/kg/day) in inhibiting recurrent partial closure of the epiphyseal plate was tested in rabbits. An epiphysiodesis was done laterally in the distal left femoral epiphyseal plate in 10 adolescent rabbits. This produced a valgus deformity in 14 of them. The bone bridge was then removed operatively and the rabbits were treated with either indomethacin or vehicle for 21 days postoperatively. Indomethacin plasma levels were about 180 ng/ml. The valgus deformity improved in indomethacin-treated rabbits, whereas it became worse in the controls (P = 0.004).
No takes yet. Share an insight, caveat, or question.
Sudmann et al. (1982) studied Recurrent partial closure of the epiphyseal plate. Indomethacin vs. Vehicle was evaluated on Change in valgus deformity (p=0.004). Indomethacin (10 mg/kg/day) improved valgus deformity in adolescent rabbits following bone bridge removal, whereas the deformity worsened in vehicle-treated controls (P = 0.004).
Synapse has enriched 10 related papers. Consider them for comparative context: