Key result
A literature review of historical active control regimens in community-acquired pneumonia allows formulation of noninferiority margins specific to age and bacteremia status.
Population
Patients with community-acquired pneumonia
Comparison
Antimicrobials (sulfonamides or penicillin) vs Placebo (historical control)
Design
Review
Authors
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May inform age- and bacteremia-specific noninferiority margins in future CAP trials; leaves open prospective validation before adoption.
This review provides a methodological framework and historical evidence basis for establishing valid noninferiority margins in trials of antimicrobials for community-acquired pneumonia.
Fleming et al. (2008) conducted a review in Community-acquired pneumonia. Antimicrobials vs. Active control regimens (sulfonamides or penicillin) was evaluated. A literature review of historical active control regimens in community-acquired pneumonia allows formulation of noninferiority margins specific to age and bacteremia status.
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