Why the study?
Does increased right ventricular afterload improve RV contractile performance in newborn lambs?
Population
9 newborn lambs
Comparison
4 hours of partial balloon occlusion of the… vs Baseline and after releasing the occlusion
Design
Preclinical
Follow-up
4 hours
Authors
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Supports homeometric autoregulation in neonatal RV; leaves open translation to human infants or clinical settings.
Does increased right ventricular afterload improve RV contractile performance in newborn lambs?
In newborn lambs, the right ventricle maintains cardiac output against increased afterload through homeometric autoregulation (improved contractile performance) rather than the Frank-Starling mechanism.
Vroomen et al. (2000) studied this question.
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