Why the study?
Does whole blood volume infusion alter left ventricular performance and contractility differently in preterm versus full-term newborn lambs?
Population
25 newborn lambs, including preterm at 122 days gestational age, preterm at 139 days gestational age, and…
Comparison
Three successive whole blood volume infusions of… vs Baseline and comparison across gestational age…
Design
Preclinical
Authors
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Animal data indicate similar Frank-Starling responses without contractility change in lambs; leaves open translation to human neonates or volume management.
Does whole blood volume infusion alter left ventricular performance and contractility differently in preterm versus full-term newborn lambs?
Preterm and full-term newborn lambs exhibit quantitatively similar Frank-Starling responses to volume infusion without increased contractility, though full-term ventricles generate greater stroke work.
Baylen et al. (1986) studied this question.
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