Key result
Retracting the pericardium increased left ventricular diameter by an average of 9.0% relative to the closed-chest, closed-pericardium state across all end-diastolic pressures (P < 0.05).
Why the study?
Do the chest wall, lungs, and pericardium limit left ventricular filling in neonatal lambs?
Population
11 halothane-anesthetized lambs (five 1-h-old lambs and six 2- to 17-day-old lambs)
Comparison
Retraction of chest wall and lungs, followed by… vs Closed chest and closed pericardium
Design
Preclinical
Authors
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Thoracic constraint on LV filling in neonatal lambs is hypothesis-generating; leaves open relevance to human infants.
Do the chest wall, lungs, and pericardium limit left ventricular filling in neonatal lambs?
Effect estimate: 9.0% increase
p-value: p=< 0.05
Thoracic tissues, primarily the pericardium immediately after birth and both the chest wall-lung combination and pericardium later, substantially limit left ventricular filling in young lambs.
Grant et al. (1994) studied this question. Retraction of chest wall, lungs, and pericardium vs. Closed chest and pericardium was evaluated on Change in left ventricular diameter (9.0% increase, p=< 0.05). Retracting the pericardium increased left ventricular diameter by an average of 9.0% relative to the closed-chest, closed-pericardium state across all end-diastolic pressures (P < 0.05).
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