Key result
Retraction of the chest wall, lungs, and pericardium significantly increased fetal right ventricular stroke volume from 1.2 mL to 4.2 mL at a Prved of 9 mm Hg (P<=0.05).
Why the study?
Do the chest wall, lungs, and pericardium limit right ventricular stroke volume in fetal lambs?
Population
6 fetal lambs (142 days of gestation)
Comparison
Retraction of chest wall, lungs, and pericardium vs Closed chest and closed pericardium (CCCP)
Design
Preclinical
Authors
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Leaves open fetal RV constraint in humans; extends prior LV pericardial findings to RV in this lamb model.
Do the chest wall, lungs, and pericardium limit right ventricular stroke volume in fetal lambs?
Absolute Event Rate: 4.2% vs 1.2%
p-value: p=<=0.05
The chest wall, lungs, and pericardium significantly constrain the fetal right ventricle and limit its stroke volume by increasing intrapericardial pressure as right ventricular end-diastolic pressure increases.
Grant et al. (1996) studied Fetal right ventricular physiology (n=6). Retraction of chest wall, lungs, and pericardium vs. Closed chest and closed pericardium was evaluated on Right ventricular stroke volume at Prved of 9 mm Hg (p=<=0.05). Retraction of the chest wall, lungs, and pericardium significantly increased fetal right ventricular stroke volume from 1.2 mL to 4.2 mL at a Prved of 9 mm Hg (P<=0.05).