Why the study?
Does the initiation of ventilation alter pericardial pressure and left ventricular function in fetal lambs?
Population
Six partially delivered fetal lambs from pregnant ewes at 142-144 days of gestation.
Comparison
Initiation of ventilation and subsequent… vs Baseline condition before ventilation.
Design
Preclinical
Follow-up
1 hour
Authors
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May enhance LV preload understanding at birth in lambs; leaves open translation to human neonates.
Does the initiation of ventilation alter pericardial pressure and left ventricular function in fetal lambs?
At birth, the initiation of ventilation reduces pericardial pressure, thereby increasing left ventricular preload and systolic function through the Frank-Starling mechanism.
Grant et al. (1992) studied this question.