Key result
Inhibition of cell migration was positively correlated with the blockage of volume-activated Cl(-) current (r=0.97), suggesting these channels are involved in tumor cell migration.
Population
Nasopharyngeal carcinoma CNE-2Z cells
Comparison
Blockage of volume-activated chloride channels… vs Control conditions (hypotonic treatments, Cl…
Design
Preclinical
Authors
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Hypothesis-generating for chloride channel blockade to limit nasopharyngeal carcinoma migration; leaves open translation to in vivo or clinical settings.
Effect estimate: r 0.97
Volume-activated chloride channels play a functional role in the migration of nasopharyngeal carcinoma cells.
Mao et al. (2007) studied Nasopharyngeal carcinoma. Blockage of volume-activated chloride channels vs. Control was evaluated on Cell migration and volume-activated Cl(-) current (r 0.97). Inhibition of cell migration was positively correlated with the blockage of volume-activated Cl(-) current (r=0.97), suggesting these channels are involved in tumor cell migration.
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