Permeation properties and modulation of volume‐activated Cl−‐currents in human endothelial cells
Population
Endothelial cells from human umbilical vein
Design
Preclinical
Authors
Discussion
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Overview
Differentiates endothelial volume-activated Cl- currents from ClC-2; leaves open their vascular roles in vivo.
Structured PICO
P
Population
Endothelial cells from human umbilical vein
I
Intervention
Pharmacological modulators (NPPB, ATP, arachidonic acid, tamoxifen, cytotoxic compounds) and various anions
O
Outcome
Permeation properties and pharmacological modulation of volume-activated Cl- currentssurrogate
Volume-activated Cl- currents in human endothelial cells share permeation and pharmacological properties with similar channels in other cell types, but differ significantly from CIC-2 channels.
Cite This Study
Nilius et al. (1994) studied this question.