Activation of a Cl- current by hypotonic volume increase in human endothelial cells.
Population
Endothelial cells from human umbilical veins
Comparison
Hypotonic extracellular solutions vs Normal osmolarity (290 mOsm)
Design
Preclinical
Authors
Discussion
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Member takes
Overview
Supports PLA2 modulation of endothelial volume-sensitive Cl- currents; leaves open physiological relevance and in vivo validation.
Structured PICO
P
Population
Endothelial cells from human umbilical veins
I
Intervention
Hypotonic extracellular solutions (HTS, 185 mOsm instead of 290 mOsm)
C
Comparator
Normal osmolarity (290 mOsm)
O
Outcome
Activation of ionic currents (Cl- current)surrogate
Hypotonic volume increase activates a Ca2+-independent Cl- current in human endothelial cells, which may be modulated by PLA2 cleavage products.
Cite This Study
Nilius et al. (1994) studied this question.