Volume regulation in a toad epithelial cell line: role of coactivation of K+ and Cl‐ channels.
Population
Distal nephron A6 cells (toad epithelial cell line)
Comparison
Hypotonic solutions with or without channel… vs Resting conditions
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Informs epithelial volume regulation mechanisms; extends amphibian cell observations but leaves open mammalian translation.
Structured PICO
P
Population
Distal nephron A6 cells (toad epithelial cell line)
I
Intervention
Hypotonic solutions (HTS) with or without channel blockers (NPPB, quinine)
C
Comparator
Resting conditions
O
Outcome
Changes in cell volume, membrane potential, and ionic currentssurrogate
Coactivation of K+ and Cl- channels is essential for regulatory volume decrease in toad distal nephron A6 cells exposed to hypotonic solutions.
Cite This Study
Nilius et al. (1995) studied this question.