Population
apically amphotericin B-permeabilized HT-29/B6 monolayers in Ussing chambers
Comparison
K+ channel blockers and osmotic changes vs Isotonic conditions
Design
Preclinical
Authors
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May inform drug effects on epithelial K+ transport; leaves open clinical relevance pending in vivo studies.
In HT-29/B6 cells, volume-sensitive K+ channels are localized to the basolateral membrane and are inhibited by lidocaine, quinidine, NPPB, and barium.
Illek et al. (1992) studied this question.
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