What question did this study set out to answer?

To evaluate whether measles antibody levels are lower in women born during the vaccine era (after 1963) and their infants compared to women born before 1963 with natural measles immunity.

February 1, 1995Journal of Medical Virology

Measles antibodies in women and infants in the vaccine era.

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Authors

MKMarilyn KacicaAlbany State University PHPatricia A. HughesBaylor University Medical Center MLMartha L. LepowAlbany Medical Center Hospital

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Implication

Observational study reveals lower measles antibody levels in vaccine-era mothers and infants, suggesting a need to lower the infant immunization age.

Key Points

To evaluate whether measles antibody levels are lower in women born during the vaccine era (after 1963) and their infants compared to women born before 1963 with natural measles immunity.
Analyzed serum samples from 202 mother-infant pairs collected between November 1990 and June 1991 at Albany Medical Center Hospital in upstate New York.
Measured measles antibody levels via enzyme immunoassay (EIA), defining seronegativity as absorbency < 0.16, and stratified results by maternal birth cohort (pre-1963 vs. post-1963).
Mothers born before 1963 and their infants demonstrated significantly higher mean EIA absorbency values than mothers born after 1963 and their infants (P < 0.002).
Seropositivity was significantly higher in pre-1963 mothers (87%) and their infants (94%) than in post-1963 mothers (61%) and their infants (69%, P = 0.0001).
Overall, 30% of mothers and 17% of infants were seronegative for measles antibodies across the 202 pairs.

Cite This Study

Kacica et al. (1995) studied this question.

synapsesocial.com/papers/6a899e8747b10e0a7dd43baa https://doi.org/10.1002/jmv.1890450220

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Implication

Observational study reveals lower measles antibody levels in vaccine-era mothers and infants, suggesting a need to lower the infant immunization age.

Measles antibodies in women and infants in the vaccine era.

Discussion

Member takes

Implication

Key Points

Cite This Study

Measles antibodies in women and infants in the vaccine era.

Discussion

Member takes

Implication

Key Points

Cite This Study

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