March 22, 2026PEDIATRICS
Changing Levels of Measles Antibody Titers in Women and Children in the United States: Impact on Response to Vaccination
Key Points
- Evaluate changes in measles antibody titers and responses to vaccination in women and children in the U.S.
- Assessed sera from children and their mothers for measles antibodies.
- Children vaccinated at 6, 9, or 12 months were included in analyses.
- Used plaque reduction neutralization to measure antibody levels.
- Examined responses based on maternal birth year and vaccination type.
- Decreased geometric mean titers of measles antibodies correlated with increasing maternal birth year.
- 93% of children born to mothers after 1963 responded to vaccination at 9 months.
- 98% of children born to the youngest mothers responded at 12 months.
- Children of women born outside the U.S. showed no association with maternal birth year.
Authors
Discussion
No takes yet. Share an insight, caveat, or question.
Implication
Data analysis reveals changing measles antibody responses in women and children, suggesting implications for vaccination timing.
Cite This Study
Markowitz et al. (1996) studied this question.