Key result
A biological age formula based on clinical variables revealed that patients with diseases had older biological ages than healthy individuals, and biological aging accelerates faster in middle age.
Cross-Sectional (n=1,373)
Yes
A newly constructed biological age formula incorporating cardiovascular, cognitive, and renal markers better reflects health condition changes of aging than chronological age in a Chinese Han population.
Should not yet change practice; leaves open validation of clinical-variable biological age formulas in longitudinal cohorts.
OBJECTIVES: Biological age (BA) has been proposed to evaluate the aging status in an objective way instead of chronological age (CA). The purpose of our study is to construct a more precise formula of BA in the cross-sectional study based on a largest-ever sample of our studies. This formula aims at better evaluation of body function and exploring the disciplines of aging in different genders and age stages. METHODS: A total of 1,373 healthy Chinese Han (age range, 19-93 years) were recruited from five cities in China, including 581 males and 792 females. Physical examination, blood routine, blood chemistry, and other lab tests were performed to obtain a total of 74 clinical variables. Then, the principal component analysis (PCA) was used to select variables and estimate BA. The BA formula was further validated in a population with some diseases (n=266), including cardiovascular diseases, type 2 diabetes, kidney diseases, pulmonary diseases, cancer and disorders in nervous system. RESULTS: The BA formula was constructed as follows: BA = 0.358 (pulse pressure) + 0.258 (trail making test) - 11.552 (mitral valve E/A peak) + 26.383 (minimum intima-media thickness) + 31.965 (Cystatin C) + 0.163 (CA) - 3.902. In validation of the formula, BAs of patients were older than those of healthy persons. The BA accelerates faster in the middle-aged population than in the elderly population (>75 years old). CONCLUSION: This BA formula can reflect health condition changes of aging better than CA in a Chinese Han population.
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Zhang et al. (2017) conducted a cross-sectional in Healthy (n=1,373). Biological age formula vs. Chronological age was evaluated on Biological age (BA). A biological age formula based on clinical variables revealed that patients with diseases had older biological ages than healthy individuals, and biological aging accelerates faster in middle age.
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