Key result
A simple multiple linear regression model based on blood pressure, ECG, and HRV indicators demonstrated a high correlation between calculated cardiovascular biological age and chronological age (r = 0.892 for women, r = 0.897 for men).
Why the study?
The study was designed to develop a simple non-invasive method for the integral assessment of cardiovascular system status to quantify age-related changes.
Does a simple non-invasive method based on BP, QT, and HRV accurately assess the biological age of the cardiovascular system in healthy individuals?
Cross-Sectional (n=339)
No
Does a simple non-invasive method based on BP, QT, and HRV accurately assess the biological age of the cardiovascular system in healthy individuals?
Effect estimate: r = 0.892 (women) and r = 0.897 (men)
p-value: p=<0.00001
A simple non-invasive method using BP, QT, and HRV can accurately estimate the biological age of the cardiovascular system, potentially identifying individuals with accelerated aging.
Offers simple non-invasive CV biological age estimation; leaves open prospective validation before clinical adoption.
We developed a simple method for assessing the biological (functional) cardiovascular system age, based on our data on age-related changes in blood pressure, ECG, and HRV. We set ourselves the task of finding a simple non-invasive method for the integral assessment of the state of the cardiovascular system, which allows us to quantify the degree of age-related changes in this system. The essence of the method lies in the fact that the BA of the cardiovascular system is calculated according to the indicators of BP, QT and HRV. The study included 339 practically healthy people from 20 to 90 years (191 women and 148 men). The formula for calculating BA was obtained by multiple linear regression. The multiple correlation between biological age and chronological is high (r = 0.892; p <0.00001 for women and r = 0.897; p <0.00001 for men). The average absolute value of the BA calculation error is 5.19 ± 0.42 years for women and 5.14 ± 0.33 for men in this case. Thus, the formulas we obtained for calculating the BA are used in medical practice. The proposed model for determining BA can be used to identify individuals with accelerated cardiovascular ageing who require more advanced instrumental and laboratory examinations. Moreover, the developed method for assessing the rate of cardiovascular system ageing can be utilised as a rapid method for scientific research.
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Pisaruk et al. (2024) conducted a cross-sectional in Healthy (n=339). Cardiovascular biological age model (BP, ECG, HRV) vs. Chronological age was evaluated on Correlation between calculated biological age and chronological age (r = 0.892 (women) and r = 0.897 (men), p=<0.00001). A simple multiple linear regression model based on blood pressure, ECG, and HRV indicators demonstrated a high correlation between calculated cardiovascular biological age and chronological age (r = 0.892 for women, r = 0.897 for men).
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