Key result
Seven biomarkers yield a biological age formula reflecting vital organ function in healthy Chinese adults.
Why the study?
Chronological age cannot distinguish functional differences among individuals of the same age, necessitating a biological age formula to reflect body functional state.
Cross-Sectional (n=505)
No
A biological age formula was developed for a healthy Chinese population incorporating seven functional biomarkers across multiple organ systems.
Requires external validation before clinical use; extends biological age estimation to healthy Chinese adults via multi-organ biomarkers.
BACKGROUND: Whereas chronological age (CA) cannot distinguish functional differences among individuals of the same age, the biological age (BA) may be used to reflect the functional state of the body. The purpose of this study was to construct an integral formula of the BA, by using principle component analysis (PCA). METHODS: The vital organ function of 505 healthy individuals of Han origin (age 35-91 years) was examined. A total of 114 indicators of cardiovascular, pulmonary, and brain functions, and clinical, inflammatory, genetic, psychological, and life habit factors were assessed as candidate indicators of aging. Candidate indicators were submitted with CA to correlation and redundancy analyses. The PCA method was used to build an integral formula of the BA for the population. RESULTS: Seven biomarkers were selected in accordance with a certain load standard. These biomarkers included the trail making test (TMT), pulse pressure (PP), mitral valve annulus ventricular septum of the peak velocity of early filling (MVES), minimum carotid artery intimal-medial thickness (IMTmin), maximum internal diameter of the carotid artery (Dmax), maximal midexpiratory flow rate 75/25 (MMEF75/25), and Cystatin C (CysC). The formula for the BA was: BA = 0.0685 (TMT) + 0.267 (PP) - 1.375 (MVES) + 22.443 (IMTmin) + 2.962 (Dmax) - 2.332 (MMEF75/25) + 16.104 (CysC) + 0.137 (CA) + 0.492. CONCLUSION: Several genetic and lifestyle indicators were considered as candidate markers of aging. However, ultimately, only markers reflecting the function of the vital organs were included in the BA formula. This study represents a useful attempt to employ multiple indicators to build a comprehensive BA evaluation formula of aging populations.
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Zhang et al. (2013) conducted a cross-sectional in Healthy (n=505). Candidate indicators of aging was evaluated on Biological age formula construction. Principal component analysis identified seven biomarkers (TMT, PP, MVES, IMTmin, Dmax, MMEF75/25, and CysC) to construct a biological age formula reflecting vital organ function in healthy Chinese adults.
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