What question did this study set out to answer?

To assess the effects of stilbestrol administration on circulating angiotensinogen levels and plasma renin activity in the absence of renal tissue.

November 1, 1969Endocrinology

Effects of Estrogens on Plasma Angiotensinogen and Renin Activity in Nephrectomized Rats

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To assess the effects of stilbestrol administration on circulating angiotensinogen levels and plasma renin activity in the absence of renal tissue.
Administered stilbestrol to bilaterally nephrectomized male, normal female, and hysterectomized female rats.
Prepared and incubated semipurified plasma angiotensinogen to test for the presence and activity of renin-like enzymatic components.
Stilbestrol administration produced an increase in plasma angiotensinogen concentration beyond the elevation caused by nephrectomy alone, alongside increased plasma renin activity across males and intact or hysterectomized females.
Semipurified angiotensinogen preparations contained minute amounts of an unidentified renin-like substance that released an angiotensin-like pressor agent upon incubation.

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Implication

Animal study demonstrates stilbestrol elevates plasma angiotensinogen and renin activity in nephrectomized rats, suggesting an extrarenal origin of renin-like activity under estrogen stimulation.

Cite This Study

Nasjletti et al. (1969) studied this question.

synapsesocial.com/papers/6a89a7e0d89205768aeb3f48 https://doi.org/10.1210/endo-85-5-967

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Implication

Animal study demonstrates stilbestrol elevates plasma angiotensinogen and renin activity in nephrectomized rats, suggesting an extrarenal origin of renin-like activity under estrogen stimulation.

Effects of Estrogens on Plasma Angiotensinogen and Renin Activity in Nephrectomized Rats

Key Points

Discussion

Implication

Cite This Study

Effects of Estrogens on Plasma Angiotensinogen and Renin Activity in Nephrectomized Rats

Key Points

Discussion

Implication

Cite This Study

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