Why the study?
Does candesartan compared to captopril increase renal plasma flow differently in normal humans on low-salt versus high-salt diets?
Population
Normal humans when in balance on a low-salt, as well as a high-salt, diet
Comparison
Candesartan at the top of the dose-response vs Captopril at the top of the dose-response
Design
Other
Authors
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May favor ARBs over ACEIs for renal hemodynamics on high salt; leaves open translation to patients.
Does candesartan compared to captopril increase renal plasma flow differently in normal humans on low-salt versus high-salt diets?
Non-ACE-dependent Ang II generation in the kidney is less influenced by salt intake than the classical ACE pathway, accounting for 60-70% of Ang II generation on a high-salt diet.
Hollenberg et al. (2001) studied this question.
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