Why the study?
Does plasma angiotensin II concentration regulate vascular and adrenal responsiveness to sodium restriction in normal humans?
Population
Normal volunteer subjects
Comparison
Angiotensin II infusion in increasing doses… vs Angiotensin II infusion during high sodium…
Design
Other
Authors
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Supports differential vascular versus adrenal regulation by endogenous ANG II during sodium restriction; leaves open applicability to clinical populations with cardiovascular disease.
Does plasma angiotensin II concentration regulate vascular and adrenal responsiveness to sodium restriction in normal humans?
Endogenous angiotensin II concentration regulates vascular responsiveness but is not necessary to maintain adrenal sensitivity during sodium restriction in normal humans.
Dawson-Hughes et al. (1981) studied this question.
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