Why the study?
Does sodium intake alter the affinity of vascular and adrenal angiotensin II receptors in animal models?
Population
Aortas derived from rabbits and glomerulosa cells obtained from rats on high or low salt intake
Comparison
Sar1, Ala8 derivative, a competitive antagonist… vs High vs low salt intake diets
Design
Preclinical
Authors
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Sodium-dependent angiotensin responsiveness differs by tissue in animals; leaves open human receptor affinity effects and clinical relevance.
Does sodium intake alter the affinity of vascular and adrenal angiotensin II receptors in animal models?
Sodium restriction blunts the vasoactive effects of angiotensin by reducing receptor affinity, while enhanced adrenal response involves intracellular biochemical changes overcoming reduced receptor affinity.
Williams et al. (1976) studied this question.
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