Key result
Studies on cardiac arrhythmogenesis have primarily focused on parenchymal cell dysfunction, including impaired ion-channel function, reduced gap junctional coupling, and abnormal calcium handling.
This paper discusses the role of fibroblast-myocyte interactions in cardiac arrhythmogenesis and heart failure.
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Traditional focus on parenchymal dysfunction may overlook fibroblast roles; leaves open their therapeutic relevance in arrhythmogenesis and HF.
Stephan Rohr (2012) conducted a review in Cardiac arrhythmogenesis and heart failure. Fibroblast-myocyte interactions was evaluated. Studies on cardiac arrhythmogenesis have primarily focused on parenchymal cell dysfunction, including impaired ion-channel function, reduced gap junctional coupling, and abnormal calcium handling.
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