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This review summarizes recent studies demonstrating that the actin-based cytoskeleton regulates the activity of many ion channels and transport proteins. Stretch-activated ion channels; channels conductive to chloride, to sodium, and to potassium; electroneutral transport proteins, including the Na(+)-K(+)-2Cl-cotransporter, the Na+/H+ exchanger, and the organic osmolyte transporter; as well as water channels are all regulated by the actin cytoskeleton. Several potential mechanisms whereby the actin cytoskeleton and microtubules regulate transport protein activity are discussed.
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Mills et al. (1994) studied this question.
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