Key result
Activation of the AT2 receptor with CGP42112 reduced TNF-α-stimulated ICAM-1 expression by approximately 53% via inhibition of NF-κB signaling, an effect partially mediated by ACE2.
Absolute Event Rate: 0.47% vs 1%
p-value: p=<0.01
Activation of the AT2 receptor suppresses TNF-α-induced ICAM-1 expression and NF-κB signaling in human coronary artery endothelial cells, an effect partially mediated by increased ACE2 activity.
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Hypothesis-generating for AT2 agonism in coronary endothelial inflammation; leaves open clinical translation.
Carretero et al. (2015) studied Vascular inflammation (in vitro). AT2 agonist CGP42112 vs. TNF-α alone was evaluated on TNF-α-mediated ICAM-1 expression (fold change) (p=<0.01). Activation of the AT2 receptor with CGP42112 reduced TNF-α-stimulated ICAM-1 expression by approximately 53% via inhibition of NF-κB signaling, an effect partially mediated by ACE2.